“We can forget the Champions League now,” sporting director Horst Heldt said.
Schalke will be missing several players, including striker Klaas-Jan Huntelaar, who has an eye injury.
Leverkusen are two points behind Dortmund in third and will seek to avoid falling further behind at Borussia Moenchengladbach, who have not lost in their past seven Bundesliga matches.
Eintracht Frankfurt are coming off a 2-0 win in Hamburg behind goals from newly signed striker Srdjan Lakic and a victory at home against Nuremberg would keep them on course for a place in Champions League qualifying, an amazing achievement for the promoted club.
VfB Stuttgart will be seeking to end a four-match losing streak when they host Werder Bremen.
In other matches today, Hannover 96 host TSG 1899 Hoffenheim and VfL Wolfsburg visit Greuther Furth.
Tomorrow, Augsburg host Mainz and Fortuna Duesseldorf travel to SC Freiburg.