All four of Brees’ touchdowns and 313 yards of his passing came in the first half, while Jonathan Vilma, who is appealing a one-year ban for his alleged role in the “Bounty” affair, made his season debut.
After making a 4-0 start to the season, the Arizona Cardinals have lost their last three games, the latest setback a 21-14 loss to the Minnesota Vikings (5-2).
Vikings running back Adrian Peterson opened the scoring with a 13-yard touchdown run as he put up 153 yards on the ground, but the game turned decisively for Minnesota when Harrison Smith returned an interception for a 31-yard score in the third quarter.
The Dallas Cowboys (3-3) won 19-14 at the Carolina Panthers (1-5), thanks to two fourth-quarter field goals from Dan Bailey, although the highlight was a superbly weighted 16-yard pass from Tony Room to Miles Austin in the third quarter.
Matt Hasselbeck fired a 15-yard touchdown to Nate Washington with 63 seconds to play, lifting the Tennessee Titans to a 35-34 comeback win over the Buffalo Bills.
Running backs Chris Johnson and Jamie Harper both rushed for a pair of scores as the surging Titans recorded back-to-back wins for the first time this season to jump back into the playoff chase in the AFC South with a record of 3-4.
The powerful Johnson rushed for 195 yards and two touchdowns.
In Sunday’s other games, the Indianapolis Colts defeated the Cleveland Browns 17-13, the Oakland Raiders edged the Jacksonville Jaguars 26-23 and the Pittsburgh Steelers beat the Cincinnati Bengals 24-17.
Additional reporting by Staff writer