Mario Balotelli could make his first appearance for Italy since the Euro 2012 final, after missing the game in Armenia due to flu-like symptoms.
Portugal will look to bounce back from their 1-0 loss to Russia when they host Northern Ireland in Group F, with captain Cristiano Ronaldo poised to win his 100th international cap.
Only two players have previously passed the 100-cap mark for Portugal and both are former teammates of Ronaldo’s — Fernando Couto (110 caps) and Luis Figo (127).
The Netherlands, meanwhile, made it three wins from three by crushing Andorra 3-0 in the last round of matches, but their next opponents, Romania, also have a 100 percent record in Group D.
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