Marseille will also take a strong lead into next week's second-leg match against Spartak Moscow after goals by Bruno Cheyrou, Taye Taiwo and Mamadou Niang, while Serbia midfielder Simon Vukcevic scored twice to give Sporting Lisbon a 2-0 win over FC Basel.
Ismael Blanco scored in injury time to salvage a 1-1 draw for AEK Athens against visiting Getafe when he backheeled the ball past keeper Roberto Abbondanzieri.
Substitute Ruben De la Red had put the Spanish club ahead in the 86th minute following a fumbled clearance in the goalmouth by Canadian midfielder Tam Nsaliwa.
The Greek team dominated after a shaky start, but missed several chances.
It was AEK's first game under caretaker coach Nikos Kostenoglou, after two successive league losses prompted Lorenzo Serra Ferrer to resign.
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