Oldham produced a huge FA Cup shock with a 1-0 third round win away to Premier League high-flyers Everton on Saturday.
Fellow League One side Huddersfield also enjoyed victory over top-flight opposition by beating Birmingham City 2-1 in the third round -- the stage when teams from English soccer's top two divisions enter the competition.
Premier League Blackburn Rovers also fell at the first hurdle, beaten 4-1 at home by Championship Coventry City and Sheffield United, also of the Championship, ensured that top-flight Bolton's FA Cup campaign came to an early end with a 1-0 away win.
Elsewhere non-league Havant and Waterlooville, in a match where both sides had a man sent-off, came from behind to draw 1-1 away to League One leaders Swansea.
Holders Chelsea beat west London rivals Queens Park Rangers 1-0 while Middlesbrough came from behind to defeat Premier League promotion hopefuls Bristol City 2-1.
Manchester United knocked Aston Villa out for the second time in two seasons, Cristiano Ronaldo and Wayne Rooney scoring late on to secure a 2-0 win.
Oldham, 13th in League One saw Scottish midfielder Gary McDonald make Everton, sixth in the Premier League, pay for fielding an under-strength side with a goal in first-half injury time.
Oldham then hung on for their first win at Goodison in 88 years as Everton striker Ayegbeni Yakubu hit the post in injury time.
"It wasn't a vastly weakened team at all, in fact I felt it was a strong team," Everton manager David Moyes insisted.
Oldham boss John Sheridan said: "I believed we could get something from the game, we have won seven on the trot away now, so we are doing something right."
Tottenham and Reading drew 2-2 at White Hart Lane while in other top-flight fixtures Wigan won 3-0 away to fellow strugglers Sunderland and West Ham and Manchester City drew 0-0.
Chasetown, the lowest-ranked club ever to reach this stage of the FA Cup, saw their run end in a 3-1 home defeat against Cardiff.