Derek Anderson threw five touchdown passes, Jamal Lewis rushed for 215 yards and the Cleveland Browns, who were so desperate after losing their opener that they traded their starting quarterback, outlasted the Cincinnati Bengals and Carson Palmer 51-45 on Sunday.
Anderson had a breakout game against the Browns (1-1), going 20-of-33 for 328 yards and the five touchdowns, tying a team record shared by Frank Ryan, Bill Nelsen, Brian Sipe and Kelly Holcomb.
Palmer went 33-of-50 for 401 yards and tossed a career-high six TDs, but his final chance to rally the Bengals (1-1) ended when he was intercepted with 21 seconds left by Leigh Bodden, who made a diving grab near Cleveland's sideline.
PHOTO: AP
It was just the third time in NFL history that two quarterbacks threw five touchdown passes in the same game. Oakland's Tom Flores (6) and Houston's George Blanda (5) both did it on Dec. 22, 1963, and Billy Kilmer of New Orleans (6) and Charley Johnson of St. Louis (6) also did on Nov, 5, 1969.
Packers 35, Giants 13
At East Rutherford, New Jersey, Brett Favre completed his first 14 passes of the second half and threw three touchdown passes to rally Green Bay over Eli Manning and New York.
The win was the 149th of Favre's 17-year NFL career, giving him one more victory than Hall of Famer John Elway.
It also gave the Packers their first 2-0 start since they won their first three in 2001.
Patriots 38, Chargers 14
At Foxborough, Massachusetts, Tom Brady threw for 279 yards and three touchdowns and got three TDs from players picked up last spring: Randy Moss with two receptions, and Adalius Thomas with a 65-yard interception return.
The win came three days after the NFL fined Patriots coach Bill Belichick and the team for spying.
Texans 34, Panthers 21
At Charlotte, North Carolina, Matt Schaub threw for 227 yards and two touchdowns and Houston forced three turnovers to recover from a sluggish start and go 2-0 for the first time in franchise history.
Houston went 24-56 in its first five years with David Carr, who was released in the offseason when the Texans traded for Schaub. Carr, now the Panthers backup, could only watch as Andre Johnson caught seven passes for 120 yards and two scores.
Colts 22, Titans 20
At Nashville, Tennessee, Peyton Manning threw for 312 yards and a touchdown and Indianapolis held off Tennessee when its defense stopped Vince Young on a final-drive comeback.
Unlike last December, when Rob Bironas capped a similar comeback with a 60-yard field goal, the Colts collapsed around Young on fourth-and-4. That forced him to lob the ball away in the final seconds.
49ers 17, Rams 16
At St. Louis, Dante Hall fumbled a punt and Marcus Hudson recovered for San Francisco, setting up the winning field goal by Joe Nedney.
The Rams' Jeff Wilkins missed a 56-yard field goal try with 59 seconds to play, the ball falling about a yard short of the goal post.
The 49ers (2-0) won despite struggling offensively most of the game. St. Louis (0-2) had 392 total yards to 186 for San Francisco. Alex Smith was 11-for-17 for 126 yards. Frank Gore scored two touchdowns and gained 81 yards on 20 carries.
Buccaneers 31, Saints 14
At Tampa, Florida, Joey Galloway caught four passes for 135 yards and two touchdowns, tormenting New Orleans for the sixth straight game between the NFC South rivals and leading the Buccaneers to a victory.
The Saints (0-2) were embarrassed for the second consecutive week and have been outscored 72-24 after having one of the NFL's most explosive offenses and reaching the NFC championship game last season.
Steelers 26, Bills 3
At Pittsburgh, Willie Parker ran for a touchdown and 126 yards and Ben Roethlisberger threw for a score as Pittsburgh controlled the clock and the tempo while pulling away from Buffalo.
It was the Bills' first game since tight end Kevin Everett badly injured his spinal cord.
Buffalo's J.P. Losman couldn't generate any offense as the Bills were outgained 421-223. The Steelers finally took control with the game's only two touchdowns in the final quarter and a half.
Jaguars 13, Falcons 7
At Jacksonville, Florida, Joey Harrington was sacked seven times as Jacksonville held Atlanta under 100 yards rushing.
Atlanta's biggest problem came on special teams, where rookie Matt Prater missed two field goals. His second miss on Sunday would have given the Falcons (0-2) a 10-3 advantage. Instead, David Garrard drove Jacksonville (1-1) on consecutive scoring drives to put the team ahead for good.
Broncos 23, Raiders 20, OT
At Denver, Jason Elam's 23-yard field goal with 5:48 left in overtime gave the Broncos a win just minutes after the Raiders had been celebrating what they thought was their own wild win.
Sebastian Janikowski nailed a 52-yard field goal at 11:13 of overtime. But the officials ruled Denver called a timeout just before the snap. On the retry, Janikowski's kick hit the left upright, giving the Broncos the ball at their 42.
Bears 20, Chiefs 10
At Chicago, Devin Hester scored on a 73-yard punt in the second quarter and set up a field goal in the third with another long return for the defending NFC champions.
Cedric Benson carried 24 times for 101 yards, eight shy of his career high for the Bears (1-1). Rex Grossman was 20-for-34 with 160 yards and a touchdown, but was picked off twice after passing for 145 yards against the Chargers.
Ravens 20, Jets 13
At Baltimore, Kyle Boller threw for 185 yards and two touchdowns as the Baltimore Ravens overcame a late charge by Kellen Clemens and the New York Jets in a matchup of backup quarterbacks.
Making his first NFL start, Clemens cut a 20-3 deficit to seven points in the fourth quarter and took the Jets (0-2) to the Baltimore 7 before Ray Lewis intercepted a deflected pass in the end zone with 1:04 left to preserve the win.
Cowboys 37, Dolphins 20
At Miami, Dallas took advantage of five takeaways and a ball-control offense to beat the hapless Miami.
The Cowboys intercepted Trent Green four times and recovered a fumbled snap. Green also fumbled attempting a spike play late in the first half, possibly costing Miami points.
Dallas came from behind to take a 20-13 lead early in the fourth quarter, then sealed the win with two touchdowns in the final 4:01.
Arizona 23, Seattle 20
At Glendale, Arizona, Darnell Dockett recovered a fumble by Seattle's Matt Hasselbeck after blowing a 17-0 lead in what looked like another classic Arizona collapse. Neil Rackers kicked a 41-yard field goal with 1 second to go, giving the Cardinals the victory over the Seahawks.
Rackers' 52-yarder tied it at 20 with 4:44 to play.
Lions 20, Vikings 17
At Detroit, Jason Hanson's 37-yard field goal in overtime lifted Detroit over Minnesota and ended a 10-game losing streak in the series.
The Lions and Vikings combined for nine turnovers in regulation and two missed field goal attempts in the final 35 seconds.
The 10th turnover -- Brooks Bollinger's fumbled snap -- gave Detroit the ball at the 50. Jon Kitna, who missed two quarters after being shaken up, ran the ball twice to pick up a key first down and Brian Calhoun's 17-yard run set up Hanson's kick.
Detroit (2-0) has won its opening two games for the first time in three years.
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