Liverpool tackle Chelsea as a resurgent City play stuttering champions United in the Manchester derby on a crunch weekend of fixtures in the English Premier League.
In the first "big four" clash of the new season, Rafael Benitez's Reds host Jose Mourinho's Blues in an early test of each side's title-winning potential.
And Manchester United head to Eastlands without last season's top two scorers: the injured Wayne Rooney, and Cristiano Ronaldo, who is suspended.
Manchester City, revitalized under former England boss Sven-Goran Eriksson, have the chance to prove their impressive start to the season makes them serious contenders this season.
The Manchester derby, Liverpool's clash with Chelsea and Arsenal's trip to Blackburn take place tomorrow.
In today's matches, league leaders Everton look to keep up their perfect start at Reading.
Big-spending Tottenham, desperate for a first win, host newly-promoted Derby County and West Ham travel to Birmingham with new signing Kieron Dyer set to make his Hammers debut.
At the Madejski Stadium, two of the toughest teams to break down in the Premier League go head to head.
Early pace-setters Everton have got the better of Tottenham and Wigan so far, but they travel to Reading, whose man-marking tactics squeezed a goalless draw out of Manchester United and gave Chelsea a fright before the Blues ground out a win.
"We'll be playing three from the top six inside a week, and it's as if it's the hardest possible hurdle we could have been set," Royals boss Steve Coppell said.
Everton's new midfielder Phil Jagielka reckons the Toffees are playing so well he faces an extended spell on the bench.
"I can't see the gaffer changing it for Reading," the England B international said. "Nine or even seven points [from the first three games] would be a fantastic start."
Tottenham were tipped to be among the top sides this season but they have lost both their matches so far.
"Now there is more pressure to get a result," said Spurs boss Martin Jol's assistant Chris Hughton.
"I'm sure Derby will try to make it difficult for us but it has to be about us and about bouncing back from two defeats," he said. "It has been a disappointing start for all of us here and we're determined to get back to winning ways."
Birmingham have been frustrated in their matches so far, losing 3-2 at Chelsea and succumbing to a disputed last-minute equalizer in a 2-2 draw at home to Sunderland.
They host West Ham -- who were embarrassed as visitors Manchester City tore them apart in a 2-0 opening day win.
England midfielder Dyer said he was ready to be thrown in to the Hammers team.
"It is probably one of my strengths -- my ability to hit the ground running, so even though I have had a bit of a stop start pre-season if the manager asks me to play at Birmingham on Saturday I would be totally up for the challenge," he said.
Newcastle boss Sam Allardyce takes charge of his first league match at St James's Park as the Magpies host Aston Villa.
England striker Michael Owen could make a welcome return for Newcastle, who have not scored at home since February.
However, Villa boss Martin O'Neill wants his defenders to close down the likes of Owen more.
"If we could just tighten up a little bit, especially when we haven't got the ball, then I honestly believe we will start to do better," the Northern Irishman said. "Once we get going, we'll be fine."
Mido should make his debut for Middlesbrough at Fulham.
Boro lost both their opening games and boss Gareth Southgate cannot wait for the tall Egyptian striker to get started.
"You want a center-forward to hold the ball up, to be a physical presence and to score goals. Mido brings all of those attributes," he said.
"Mido is a player I believe possibly has a point to prove. He is a player of great ability, a strong player and a big character," Southgate said.
Roy Keane's Championship winners Sunderland travel to Wigan looking to capitalize on their four points from six games so far.
Portsmouth host Bolton, who have lost both their opening games.
‘CRIMINAL ACT’: The UCI said it ‘strongly condemns’ Dylan Groenewegen’s ‘dangerous behavior,’ which left Jakobsen in critical condition and injured other cyclists Dutch cyclist Fabio Jakobsen was in a coma on Wednesday, in “serious” condition, after he was thrown into and over a barrier at 80kph in the conclusion to the opening stage of the Tour de Pologne. Footage showed 23-year-old Jakobsen, of the Deceuninck-Quick-Step, racing elbow-to-elbow with fellow Dutchman Dylan Groenewegen of Jumbo-Visma as both men frantically tussled in a tight sprint to the line in Katowice. However, Jakobsen came off worst, somersaulting over the barriers before colliding with a photographer after Groenewegen had veered suddenly to the right, squeezing his rival into the security wall. “His condition is very serious. His life is
WEEKEND MATCHES: While Tatung FC made good on their chances early on, Taiwan Steel rallied to win the game 2-3 and move to the top with Taichung Futuro Sunday’s action saw Taichung Futuro, Taipower FC and Taiwan Steel tied for first place on 30 points in the Taiwan Football Premier League, while Hang Yuan FC picked up a point to take the No. 4 spot on 25 points after holding Taipower to a scoreless draw. In Taoyuan, Tatung FC hosted Taiwan Steel. It was an exciting matchup, as the visitors rallied from 2-0 down to take the game with three goals. Tatung made good on their chances early on. Honduran midfielder Elias Argueta opened the account 15 minutes into the game with a low shot from the right. Three minutes
Ronnie O’Sullivan delivered a scathing attack on the next generation of snooker players after he made the quarter-finals of the World Snooker Championship on Sunday, ending Chinese star Ding Junhui’s world championship dream. The mercurial 44-year-old Englishman won an enthralling high-quality second-round encounter 13-10 to set up a quarter-final clash with three-time champion Mark Williams. When asked by the BBC whether he thought he would remain at the top of the game for this long, the Briton, who turned professional in 1992, said the poor quality of younger players had secured his position and that something drastic would have to happen
Max Verstappen informed his Red Bull team that he would not be driving “like a grandma” in Formula One’s 70th Anniversary Grand Prix on Sunday — and he was as good as his word. The Dutch 22-year-old seized his opportunity at Silverstone, ending dominant Mercedes’ run of four successive wins this season and moving up to second place overall, 30 points behind leader Lewis Hamilton. Verstappen’s confidence shone through early on, after slotting into third place behind the two Mercedes, when he was told by race engineer Gianpiero Lambiase to take care of his tires. “Mate, this is the only chance of being