In the 110m hurdles, Terrence Trammell led from the start to win in 13.19 despite a strong comeback from fellow American Ryan Wilson, second in 13.22.
"I'm very grateful for the win. I'll take it," Trammell said. "This is my first time running in one month. It was my decision after the US trials to stay back home and make sure I was healthy before I came to Europe."
Maryam Yusuf Jamal of Bahrain broke away from the field in the last lap to win the women's 1,500m in 4:00.43, ahead of Bouchra Chaabi of Morocco, who posted a personal best in 4:03.62.
In the men's 3,000m, world 5,000m and 10,000m record-holder Kenenisa Bekele of Kenya took matters in his hands after 2km to cut the finish line in 7:29.32. Moses Kipsiro of Uganda grabbed second in 7:32.03.
In pole vault, Danny Ecker of Germany cleared 5.87m on his first attempt to beat Steve Hooker of Australia, who also reached that mark but on his second attempt. Olympic champion Tim Mack cleared 5.50m, but failed in his three attempts at 5.60m.
In other events, Clement Campbell of Jamaica won the men's 100m in 10.17, beating Wallace Spearmon in a photo finish.
Brian Johnson leaped 8.18m to edge Chris Tomlinson of Britain in the long jump.
Eriks Rags of Latvia won the javelin with a throw at 80.01m, ahead of Teemu Wirkkala and Stephan Steding of Germany.
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