Kevin Millwood (4-6) won his second straight start after going seven games without a victory since April 13 with two stints on the disabled list.
Craig Biggio singled in the fifth inning for his 2,993rd career hit and Mike Lamb went 2-for-4 for Houston.
Orioles 7, Diamondbacks 1
At Phoenix, Brian Roberts tripled and homered and drove in three runs and Baltimore took advantage of three Arizona errors for the Orioles' third straight win. The Diamondbacks swept the Orioles last weekend in Baltimore.
Daniel Cabrera (6-8) held the Diamondbacks hitless for five innings until Eric Byrnes led off the sixth with a double to left.
Red Sox 2, Padres 1
At San Diego, Daisuke Matsuzaka escaped a first-inning jam to outpitch Greg Maddux and lead Boston in a matchup of two of baseball's top teams.
Matsuzaka walked the first three batters but gave up just one run. Matsuzaka (9-5) allowed one run and five hits in six innings, striking out nine and walking five.
Reds 16, Mariners 1
At Seattle, David Ross and Brandon Phillips both hit two homers and Aaron Harang worked eight strong innings for Cincinnati on the night Ken Griffey Jr. was honored by the city where he became a star.
Playing his first game in Seattle since being traded after the 1999 season, Griffey, who was received with adulation and appreciation from the fans, went 1-for-5 with three strikeouts.
Harang (8-2) won his third straight decision, allowing two hits and a run in eight innings.
Ross and Phillips homered in the third and again in the sixth.
Angels 5, Pirates 4
At Anaheim, California, Orlando Cabrera homered and had three RBIs, including a run-scoring single in the bottom of the 11th inning as the Los Angeles Angels edged Pittsburgh.
With one out in the 11th, Chone Figgins tripled into the right-field corner against Jonah Bayliss (4-3). Cabrera lofted a 1-0 pitch into the right-field corner. The ball bounced into the seats, but was scored a single because Cabrera never touched second base.
Yankees 7, Giants 3
At San Francisco, Alex Rodriguez had four hits and two RBIs for the New York Yankees, who downed San Francisco to snap a three-game losing streak.
Barry Bonds hit his 749th career home run and 15th of the season in the eighth for the Giants, who lost their season-high eighth straight.
Rodriguez's double started a three-run second inning and he also had RBI singles in the fifth and ninth.
Matt Cain (2-8) allowed five runs and seven hits in five innings and dropped to 0-5 in his last seven starts.
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