Gary Sheffield hit a solo homer in the seventh, helping Detroit win the first two games of a three-game series between last year's World Series teams. The homer was the 463rd of Sheffield's career, moving him past Jose Canseco for 30th on baseball's all-time list.
Reds 10, Indians 5
At Cleveland, Brandon Phillips hit a three-run homer against his former team and extended his hitting streak to 21 games, leading Cincinnati over Cleveland.
David Ross also hit a three-run homer as the Reds won for the second time in eight games.
Travis Hafner homered for Cleveland, which lost for the fourth time in 19 games at Jacobs Field.
Orioles 3, Nationals 2
At Washington, Jay Payton's two-run double in the 11th inning helped Baltimore rally to defeat Washington.
The Orioles trailed most of the game before tying it in the eighth on pinch-hitter Aubrey Huff's sacrifice fly to center.
Rockies 6, Royals 4
At Denver, Brad Hawpe and Garrett Atkins hit home runs off Gil Meche -- the first earned runs the right-hander allowed on the road this season -- as Colorado beat Kansas City.
Todd Helton also homered and scored three runs for the Rockies, who received an impressive start from Taylor Buchholz (2-2).
Angels 6, Dodgers 2
At Anaheim, California, Mike Napoli homered and scored the go-ahead run on a double play, Robb Quinlan drove in two more with a bloop double and the Angels won their second straight game in the Freeway Series.
The Angels have won nine of their last 11 to move a season-high eight games over .500. They have also beaten the Dodgers in 13 of the last 16 meetings at Angel Stadium, including Friday night's 9-1 rout.
Athletics 4, Giants 2
At Oakland, California, Dan Haren allowed three hits over seven dominant innings and Jack Cust hit a three-run homer in Oakland's second straight victory in the Bay Bridge Series.
While Barry Bonds played in his ninth straight game without hitting a homer, Cust added his eighth homer in 13 games since joining the A's.
Mariners 7, Padres 4
At Seattle, Jose Guillen homered and drove in four runs against Greg Maddux and Seattle beat San Diego.
Guillen hit a two-run homer in the first inning and a two-run double in the second. The homer was just the second allowed by Maddux.
Adrian Beltre added a solo home run off Maddux in the third inning.
Horacio Ramirez (4-2) allowed three runs in six innings.
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