Tom Glavine closed within five wins of 300, while the New York Yankees lost the game and yet another pitcher to injury against their cross-town rivals, the New York Mets.
David Wright hit a pair of two-run homers off reliever Mike Myers after Darrell Rasner broke his index finger in the first inning, and the Mets held off their fading Big Apple rivals 10-7 on Saturday for their second consecutive victory in the Subway Series.
The Yankees (18-23) lost for the seventh time in nine games and matched their low-water mark in a dismal season. The National League East-leading Mets have won nine of 11 overall.
Super sub Endy Chavez had four hits a day after delivering the go-ahead homer in the Mets' win against the Yankees. Staked to a six-run lead, Glavine (5-1) lasted six-plus innings for his 295th career victory.
All-Star second baseman Robinson Cano made three errors for the Yankees.
He also homered, grounded into an inning-ending double play with two on and struck out with runners at the corners in the ninth.
Alex Rodriguez and Jorge Posada hit consecutive solo homers in the eighth for the Yankees.
Rasner (1-3) was struck on his pitching hand by Chavez's comebacker in the first, breaking a finger and making him the latest Yankees starter to go down with an injury.
Cubs 11, White Sox 6
At Chicago, Derrek Lee, who had missed the previous five games with neck spasms, punctuated a six-run eighth inning with a pinch-hit grand slam to lead the Cubs to a second straight comeback win over the White Sox.
Paul Konerko homered leading off the top of the eighth on Saturday against Bob Howry (1-3) to put the White Sox up 6-5.
Red Sox 13, Braves 3, 1st game
Braves 14, Red Sox 0, 2nd game
John Smoltz earned his 199th victory and Atlanta had 12 extra-base hits -- one off the franchise record -- as the Braves handed Boston its worst shutout loss in 17 years to split a day-night doubleheader.
The Red Sox took the opener as Daisuke Matsuzaka (6-2) won his fifth straight decision and Mike Lowell hit a grand slam.
Julio Lugo, Kevin Youkilis and Wily Mo Pena also homered for the Red Sox in the opener. Anthony Lerew (0-2) was the loser.
Twins 5, Brewers 2
At Milwaukee, Scott Baker pitched into the ninth inning in his first major league appearance this season and Minnesota won its 12th straight interleague game.
Torii Hunter hit a two-run homer off Dave Bush (3-4) in the second as the Twins beat their regional rival for the fifth time in a row.
Marlins 7, Devil Rays 2
At St. Petersburg, Florida, Dontrelle Willis allowed two runs in seven innings, Jeremy Hermida and Aaron Boone homered on consecutive pitches in the sixth Florida beat Tampa Bay.
Willis (6-3) stopped a personal two-game losing streak. He gave up five hits, three walks and struck out seven.
Blue Jays 13, Phillies 2
At Philadelphia, Matt Stairs hit a grand slam, Lyle Overbay drove in four runs with a triple and homer and Toronto routed Philadelphia.
Troy Glaus also homered for the Blue Jays, who tagged Jamie Moyer for seven runs.
Astros 6, Rangers 1
At Houston, Lance Berkman hit a two-run single after an umpire's missed call in the sixth inning and Houston went on to beat Texas.
The Astros won for the seventh time in 10 home games. Texas has lost nine of 12.
Tigers 8, Cardinals 7
At Detroit, Ivan Rodriguez's three-run homer in the third inning gave Detroit a six-run lead.
RSS