Jose Guillen, Kenji Johjima, Betancourt and Jose Lopez -- the bottom four batters in Seattle's starting lineup -- combined to go 9-for-18 with 10 RBIs.
Athletics 5, Devil Rays 2
At St. Petersburg, Florida, Nick Swisher hit a tiebreaking three-run homer with two outs in the ninth inning for Oakland.
Shannon Stewart walked and Mark Ellis singled off Gary Glover (0-2) with one out in the ninth. Reliever Brian Stokes struck out Eric Chavez before Swisher hit a 2-2 pitch into the right-field stands.
Red Sox 2, Twins 0
At Minneapolis, Tim Wakefield limited Minnesota to three hits in seven innings and David Ortiz homered to lead Boston to its third straight win.
Wakefield (3-3) didn't allow a runner past second base against the AL's top-hitting team.
Rangers 7, Blue Jays 1
At Arlington, Texas, Hank Blalock hit a two-run homer, Brandon McCarthy pitched six sharp innings and Texas snapped a five-game losing streak.
McCarthy (2-4) allowed one run and two hits with four walks.
Tigers 6, Royals 3
At Kansas City Missouri, Justin Verlander maintained his mastery of Kansas City and Detroit won its fifth straight.
The hard-throwing Verlander gave up seven hits and two runs in seven-plus innings. Todd Jones worked the ninth for his league-leading 11th save in 13 chances.
Angels 5, White Sox 1
At Anaheim, California, Kelvim Escobar allowed one run in seven innings and Los Angeles beat Chicago to make Mike Scioscia the most successful manager in franchise history.
Escobar (3-1) struck out four and walked two.