Daisuke Matsuzaka's lack of control in a key situation cost him against the Toronto Blue Jays.
Dice-K struck out 10 over six innings but forced in the go-ahead run with a bases-loaded walk to Gregg Zaun in the fourth, and Toronto beat the Boston Red Sox 2-1 on Tuesday night despite getting just three hits.
Matsuzaka (1-2) retired his first eight batters and Wily Mo Pena's third-inning homer gave him a lead, but Lyle Overbay's single tied the score in the two-run fourth.
Jason Frasor, taking over as closer while B.J. Ryan is sidelined by a sprained elbow, got four outs for his first save since Sept. 20, 2005, against Seattle.
Matsuzaka allowed three hits and three walks in six innings. He struck out 10 for the second time in three starts -- the last pitcher to reach double-digit strikeouts twice in his first three major league starts was the Los Angeles Dodgers' Fernando Valenzuela in 1981.
Gustavo Chacin (2-0) allowed one run and six hits in 6 2-3 innings, and Casey Janssen got three outs before Frasor came in.
Devil Rays 6, Orioles 4
St. Petersburg, Florida, Rocco Baldelli had a two-run single during a six-run fourth inning and Tampa Bay stopped Baltimore's four-game winning streak.
Steve Trachsel (0-1) remained winless in three starts with the Orioles, allowing six runs and six hits in 3 2-3 innings as his ERA rose from 2.63 to 5.19.
Tampa Bay starter Casey Fossum (1-1), gave up three runs and five hits in seven-plus innings.
Tigers 7, Royals 6
At Detroit, Placido Polanco hit the tiebreaking single with two outs in the eighth inning and Detroit extended Kansas City's losing streak to six.
Polanco also hit a solo home run and tripled, Magglio Ordonez had three hits and three RBIs and Marcus Thames homered.
David DeJesus had four hits with a homer and scored three runs for Kansas City.
With the score 6-6, Omar Infante singled to lead off the eighth and was sacrificed to second by Neifi Perez. One out later, Polanco singled off David Riske (0-2).
Yankees 10, Indians 3
At New York, Alex Rodriguez helped make Chase Wright an easy winner in his big league debut.
Rodriguez hit his major league-leading eighth home run, and Jorge Posada and Doug Mientkiewicz also connected in the second inning off an ineffective Jake Westbrook.
Posada, who hit his 200th career homer, and Rodriguez each had three RBIs.
Called up from Double-A Trenton to fill a spot in New York's injury-depleted rotation, Wright (1-0) showed impressive poise following a shaky start. He allowed three runs and five hits in five innings.
Rangers 8, White Sox 1
At Chicago, Sammy Sosa tuned out the boos and showed Chicago what it's been missing the last few years.
Sosa sparked Texas' rout with a three-run homer in his return to the Windy City, the 591st home run of his career.
Brad Wilkerson and Ian Kinsler also homered for the Rangers to back Robinson Tejeda (2-1). Kinsler's homer was his seventh.
Sosa, who was booed in each at-bat, finished 2-for-4.
Athletics 4, Angels 1
At Oakland, California, Bobby Crosby broke a scoreless tie with a three-run homer in the fourth for Oakland, spoiling the season debut of Jered Weaver.
The drive to left-center in the decisive fourth inning helped Chad Gaudin (1-0) pick up his first victory of the year. Gaudin allowed four hits in 7 2-3 innings, allowing an RBI double to Maicer Izturis in the eighth for the Angels' lone run.