Carlos Diogo scored a 78th-minute goal and gave Zaragoza a 1-0 victory over FC Barcelona in the first leg of their Copa del Rey quarterfinal at Camp Nou stadium on Wednesday.
Uruguayan defender Diogo headed in Andres D'Alessandro's corner to threaten Barcelona's hopes of winning Spain's knockout competition for the first time since 1998.
In other games, Getafe and Deportivo La Coruna took firm strides toward the semifinals.
Getafe downed visiting Osasuna 3-0 to move closer to its debut appearance in the last four, while Deportivo La Coruna rallied to beat second-division Valladolid 4-1.
Barcelona, who were eliminated by Zaragoza in the last season's quarterfinals, will have to rally away from home in the return leg on Feb. 28.
The European champion's clearest first-half chance arrived in the 30th minute when Andres Iniesta was set free by Javier Saviola's pass, but the midfielder couldn't get past goalkeeper Cesar Sanchez.
Zaragoza, the Copa del Rey winners in 2001 and 2004 and losing finalist last year, took control just before halftime.
Barcelona goalkeeper Albert Jorquera managed to parry Oscar Gonzalez's goalbound shot with his legs in the 41st minute and Sergio Garcia hit the home side's post with a shot two minutes later.
The second half brought few opportunities, with Saviola shooting over in the 67th minute and D'Alessandro firing wide moments before Diogo's winning goal.
Getafe striker Daniel Guiza headed his side's first goal in the 10th minute from close range after Fabio Celestini nodded on Mario Cotelo's corner.
A Cotelo corner 29 minutes later provided defender Alexis Ruano with the chance to head in Getafe's second goal, while substitute Maris Verpakovskis capitalized when goalkeeper Ricardo Lopez dropped a cross in the 55th to add a third.
Getafe, appearing in the last eight of Spain's knockout competition for the first time, visit Pamplona in the second leg on Feb. 28.
Valladolid striker Vladimir Manchev, making his debut after transferring from Levante, put the visitors ahead in the 22nd minute.
Two-time champion Deportivo, however, took the lead on goals by Pablo Alvarez and Ruben Rivera in the 53rd and 67th minutes, and added insurance with a pair of goals by Joan Verdu and Juanma Delgado in the final two minutes.
Deportivo defender Albert Lopo was ejected in injury time.
Valladolid's defeat at the Riazor stadium ended the second-division leader's 21-game unbeaten run in league and cup games.
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