"It's always beautiful to play against British teams because of the history, the passion and the fair play," AC Milan director Umberto Gandini said. "Celtic is doing well in its own championship and had success against Manchester United in the group stage, which is no mean feat."
English league leader Manchester United has a chance to make up for last season's disappointing exit from the group stage, when it drew 0-0 at home to Lille and lost 1-0 away. United finished last in the group.
"We had a bad experience last year but this is a different United team," said Red Devils manager Alex Ferguson. "It's an emerging team, which is getting better all the time. We're really looking forward to the tie."
The last of Inter Milan's two European titles came in 1965. It faces Valencia, runner up in 2000 and 2001.
Arsenal has avoided the strongest teams, a boon since it is shaky this season and in sixth place in the Premier League, 18 points behind United.
Lyon is chasing a record sixth straight French title and looks a strong candidate for a first European success, but must get past 1984 runner-up Roma.
The Italian club finished fifth in Serie A last season but was promoted to second because Juventus, AC Milan and Fiorentina were all punished over a match-fixing scandal.
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