Baltimore opened a two-game lead over Cincinnati in the AFC north with a 26-20 victory over the Bengals.
In the AFC South, Tennessee's Vince Young threw three interceptions in the worst performance of his rookie season as the Titans endured a 37-7 loss to Jacksonville.
In a rematch of last season's AFC title game, AFC West leaders Denver downed Super Bowl champions Pittsburgh 31-20.
In other games, San Francisco edged Minnesota 9-3 and San Diego downed Cleveland 32-25.
In St. Louis, Damon Huard Huard threw for three touchdown passes in Kansas City's 31-17 victory over the struggling Rams, while Buffalo snapped a three-game skid with a 24-10 victory over Green Bay.
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