Spanish international winger Jose Antonio Reyes will also miss the match so former England captain David Beckham is likely to start.
AC Milan, labouring in the Italian league after their points' penalty for match-fixing, lead Group H after a win and a draw and travel to Belgium to face Anderlecht.
Milan have had problems finding the net in recent times drawing their last four matches.
But international striker Pippo Inzaghi believes Milan just need a change of luck.
"The right spirit is there, we just aren't getting the breaks. But if we play like we know we can, we'll get back to winning ways," he said.
Elsewhere today, Group E leaders Lyon travel to pointless Dynamo Kiev, FC Porto face Hamburg in Group G with Lille welcoming AEK Athens in Group H.
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