Premier LeagueAustralia striker Mark Viduka's 90th minute winner saw Middlesbrough beat English Premiership champions Chelsea 2-1 at the Riverside on Wednesday.
Emanuel Pogatetz headed in a Fabio Rochemback free-kick with 10 minutes remaining to level the scores after the visitors, in their second league match of the season, had seen £30 million (US$56.7 million) striker Andriy Shevchenko score his first Premiership goal for the Londoners in the 16th minute.
It gave 'Boro's rookie manager Gareth Southgate a notable scalp especially as he had seen his side surrender a 2-0 lead on Saturday and end up losing 3-2 to Reading.
Elsewhere Manchester United made it two wins from two, and so went top of the table, by defeating Charlton 3-0 at The Valley, with goals coming from Darren Fletcher, Louis Saha -- his second in two matches -- and veteran striker Ole Gunnar Solskjaer.
Fletcher pounced on a slip by Jonathan Fortune and kept his composure before firing past Scott Carson and finding the roof of the net.
Saha then fired an unstoppable low shot past Carson late on before Solskjaer produced a composed finish from Saha's cross.
"It was a great performance by us with Gary Neville ruled out this morning and others missing, it's a real demonstration of how strong the pool is," said United manager Sir Alex Ferguson. "It's a maturing team, the young players like Fletcher and O'Shea are growing up."
And Ferguson was especially pleased Solskjaer had score his first league goal for three years after career-threatening injuries.
Australia's Tim Cahill came off the bench to grab an equalizer for Everton in a 1-1 draw against Blackburn at Ewood Park.
South African striker Benni McCarthy had opened the scoring early in the second half, his shot creeping in following a run into the area by David Bentley.
Everton had a penalty appeal turned down before Cahill then swept home after confusion in the Rovers penalty area.
It was a tale of two penalties as Jimmy Bullard's stoppage-time spot-kick cancelled out El-Hadji Diouf's 73rd minute penalty to ensure a 1-1 draw for Fullham against Bolton at Craven Cottage.
Diouf opened the scoring after Gary Speed was brought down by Luis Boa Morte but Abdoulaye Faye's handball gave Bullard a chance to level.
Meanwhile Martin O'Neill's first home game as Aston Villa manager ended in victory as his side came from a goal behind to defeat Premiership newcomers Reading 2-1 at Villa Park.
The visitors took the lead after four minutes when Korean star Seol Ki-Hyeon twisted and turned on the right flank before crossing for Kevin Doyle, who headed home from close range.
Villa leveled after 34 minutes through Juan Pablo Angel's penalty after Ibrahima Sonko brought down Luke Moore, with the Royals center-back receiving a red card. Gareth Barry nodded in the winner from Peter Whittingham's cross.
Manchester City and Portsmouth played out a goalless draw at Eastlands in a match where Pompey midfielder Pedro Mendes was carried off on a stretcher after being sent crashing into the advertising hoardings by Ben Thatcher.
Arsenal booked their place in the Champions League group stage but needed a late comeback to spare their blushes and see off Dinamo Zagreb 2-1 at the Emirates Stadium on Wednesday and 5-1 on aggregate.
The English Premiership side -- last season's beaten finalists -- led the Croatian title-holders 3-0 from the third qualifying round first leg in Zagreb and were looking to cruise past them again in the first European-level match at Arsenal's shiny new home.