Pujols' two-run homer off loser Tony Fiore put the Dominican Republic (2-0) ahead for good 4-3 in the third inning. Beltre, who has eight RBIs in two games, hit a three-run shot off Italian League pitcher Riccardo De Santos in the fifth.
Moises Alou added a solo homer off Alessandro Maestri in the seventh.
Cuba 11, Netherlands 2
At San Juan, Puerto Rico, Yoandry Garlobo went 4-for-5 with three RBIs to help Cuba advance to the second round of the World Baseball Classic.
Osmany Urrutia also hit a three-run homer for Cuba (2-0), which faces Puerto Rico on Friday in a matchup of the only two undefeated teams in Group C. Puerto Rico also moved into the second round with Cuba's victory over the Netherlands.
Randall Simon had a two-run single to left in the sixth for the Netherlands (0-2).
Cuba finished the game with 16 hits.
Mexico 9, Canada 1
At Phoenix, Arizona, Jorge Cantu homered and drove in three runs and Esteban Loaiza allowed a run in five-plus innings to lead Mexico to the win.
Erubiel Durazo also had three hits and Mario Valenzuela had a solo home run for Mexico (2-1).
Canada starter Jeff Francis retired the first two batters in the first inning, then drilled Vinny Castilla in the ribs with a fastball. Consecutive doubles by Durazo, Geronimo Gil, Luis Alfonso Garcia and Miguel Ojeda made it 4-0 as Francis struggled through the 26-pitch inning.
Canada dropped to 2-1.
Venezuela 2, Australia 0
At Kissimmee, Florida, Ramon Hernandez homered and Kelvim Escobar helped pitch Venezuela into the second round of the World Baseball Classic.
The win sends Venezuela (2-1) and the Dominican Republic (2-0) to San Juan, Puerto Rico, for games beginning Sunday in a loaded group that also includes Puerto Rico and Cuba.
Led by a pitching staff sprinkled with major league aces, Venezuela allowed only three total hits in consecutive shutouts over Italy and Australia the past two nights.
Escobar allowed one hit and struck out five in 4 2-3 innings for the win.
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