Peter Crouch scored Saturday to give Liverpool a 1-0 win over Manchester United in the FA Cup, the club's first over the Red Devils in the competition since 1921.
Crouch's 19th-minute goal was his first in eight matches and made him the first Liverpool striker to score this year.
In other fifth-round matches Saturday, Charlton beat League One Brentford 3-1, while Bolton and West Ham will replay after a 0-0 draw. Newcastle beat Southampton 1-0.
At Anfield, Edwin van der Sar had stopped a header by Harry Kewell but Liverpool went ahead from the resulting corner. Crouch headed Steven Gerrard's corner kick toward goal and the United goalkeeper could only pushed the ball on to the post, from where it bounced into the net.
Manchester United's bad day got worse in the last minute when substitute Alan Smith landed awkwardly on his left leg after jumping to block John Arne Riise's kick. He was carried from the field on a stretcher with his leg strapped and taking oxygen through a face mask.
"He has broken his leg and dislocated the ankle joint," Manchester United manager Alex Ferguson told MUTV. "It is a bad one. He has gone to hospital, it looks very long term -- it is one of the worst I have seen. I am sure he will be back."
The England international's treatment resulted in seven minutes of injury time and is certain to rule him out of the June 9-July 9 World Cup.
"As a manager you do not want to see any player hurt," Liverpool manager Rafa Benitez said. "But sadly this is football and I can only offer my concern and just enjoy the victory."
Liverpool was seeking to atone for last month's 1-0 Premier League loss at Old Trafford and dominated possession. Manchester United captain Gary Neville had riled Liverpool fans in that game by celebrating the goal in front of them and was jeered Saturday whenever he touched the ball.
Neville had objects including a half-eaten burger thrown at him during the second half.
United, the record 11-time FA Cup winner and last year's runner-up, was without defender Rio Ferdinand, who sustained a hamstring injury in training. However, it was the central midfield partnership of Darren Fletcher and Ryan Giggs that struggled to compete with the home side's abrasive Mohamed Sissoko and Steven Gerrard.
"Liverpool can play for only five minutes and win the game, that is the way they are," Ferguson said. "They pump the ball into the box and with good set-piece delivery they keep you under pressure."
Charlton won a quarterfinal place for the first time in six seasons. The Addicks went 3-0 up through Darren Bent, Jay Bothroyd and Bryan Hughes before a late goal by Brentford's Isaiah Rankin.
Charlton hasn't won the FA Cup since its single 1947 win.
"For a club like us it is a route for success," Charlton manager Alan Curbishley said. "I have never managed to get past the quarterfinal stage in the 15 seasons I have been here.
"This was a chance to keep the season going, although we still need to win a few more games in the Premiership as we need to get back into the top 10."
Newcastle, a six-time FA Cup winner which last won the trophy in 1955, was without injured captain Alan Shearer, giving Kieron Dyer his first start since Aug. 28. Dyer, whose hamstring injury was complicated by an illness, scored in the 68th minute on a pass from Charles N'Zogbia.
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