In Nashville, Tennessee, Byron Leftwich threw for three touchdowns for the first time in his NFL career and ran for another score as Jacksonville (7-3) won its third straight in its best start since the 1999 season.
Leftwich finished 22-of-38 for 258 yards with TD passes to Kyle Brady and Ernest Wilford, helping the Jaguars win for the second time in three games in the rivalry.
Giants 27, Eagles 17
In East Rutherford, New Jersey, Eli Manning threw three touchdown passes, including a 61-yarder to Plaxico Burress late in the fourth quarter, as New York held off a Philadelphia team without Donovan McNabb and Terrell Owens.
In place of McNabb, who is sidelined with a groin injury, third-string quarterback Mike McMahon ran for one touchdown and threw for another.
Ravens 16, Steelers 13, OT
In Baltimore, Matt Stover kicked a 44-yard field goal with 4:09 left in overtime as Baltimore snapped a four-game losing streak.
The winner came at the end of a 30-yard drive that included an 11-yard pass from Kyle Boller to Randy Hymes on third-and-9 from the Baltimore 45.
Boller completed 21 of 36 passes for 163 yards, and his 3-yard touchdown pass to Randy Hymes in the second quarter ended a run of 12 straight quarters without a TD for the Ravens (3-7).
Patriots 24, Saints 17
In Foxborough, Massachusetts, Tom Brady threw three touchdown passes and led two scoring drives of more than 90 yards.
The loss spoiled Saints quarterback Aaron Brooks' 116th touchdown pass that broke Archie Manning's team record.
Broncos 27, Jets 0
In Denver, Jake Plummer threw for 225 yards and no interceptions, Mike Anderson ran for three scores and Denver recorded its first shutout in eight years.
Plummer went 18-for-26 and increased his team-record streak to 219 straight passes without an interception. Anderson ran for 113 yards and Denver (8-2).
New York (2-8) lost its fifth straight, went without a touchdown for the third time this season and was shutout for the first time since 1995.
Chargers 48, Bills 10
In San Diego, Drew Brees threw for 339 yards and a season-high four touchdowns, and San Diego overcame the loss of Pro Bowl tight end Antiono Gates to an injury to win its third straight.
Brees completed 28 of 33 passes, and the Chargers (6-4) scored on five of their first seven first-half possessions.
Seahawks 27, 49ers 25
In San Francisco, Shaun Alexander rushed for 115 yards and two touchdowns, and Seattle stopped San Francisco's 2-point conversion attempt with 28 seconds left for their sixth straight victory and an NFC-leading 8-2 record.
Matt Hasselbeck was 19-of-31 for 233 yards and one TD as the league's most prolific offense dominated the first three quarters, accumulating 357 yards.
Chiefs 45, Texans 17
In Houston, Larry Johnson broke the Chiefs' rushing record with 211 yards and scored two touchdowns. The record was 200 yards, which Barry Word set in 1990.
The third-year player has gained more than 100 yards in both of his starts since Priest Holmes was placed on injured reserve because of head and neck injuries.
The 211 yards were the most allowed to a single player in Texans history and the seventh time this season an opponent has gained more than 100 yards against the Texans' league-worst run defense.
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