The Diamondbacks won the season series 13-5 after going 3-16 against Los Angeles last season. They were 8-1 at Dodger Stadium, becoming the first team to beat the Dodgers eight times in Los Angeles in the same year.
Brandon Lyon pitched the ninth for his 14th save, allowing Dioner Navarro's third homer.
Left-hander Odalis Perez, making his second start since Aug. 17, and limited to four innings before the game by Dodgers manager Jim Tracy, allowed one hit and retired 12 of the 14 batters he faced before rookie Franquelis Osoria (0-3) took over.
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