The National League West-leading Padres won for just the third time in 10 games, a span in which they've scored just 21 runs.
Hernandez homered to left on a 2-2 pitch from Dustin Hermanson (0-2), who blew his first save in 16 chances. He was trying to preserve a win for left-hander Mark Buehrle, who has four straight no-decisions.
Sean Burroughs followed with a single to left, pinch-hitter Robert Fick singled to right and pinch-hitter Mark Sweeney was intentionally walked to load the bases.
Scott Linebrink (3-1) pitched the ninth for the win.
Indians 7, Giants 6
In San Francisco, Ronnie Belliard had three hits, a homer and drove in two runs, helping Cleveland become the latest team to beat up on San Francisco ace Jason Schmidt (3-3).
Grady Sizemore and Victor Martinez also had two RBIs apiece to back Jason Davis (3-2), who allowed three runs and nine hits in seven innings. The Indians assured themselves of at least a .500 finish on their season-high 12-game road trip, winning for the sixth time with one game left.
Bob Wickman came in with two men on and none out in the ninth and allowed both runners to score. He put two more men on before striking out J.T. Snow to end the game for his 16th save in 19 chances.
The Giants (25-35) lost for the 13th time in 15 games, falling 10 games under .500 for the first time since finishing 68-94 in 1996.
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