PSV started the second half in fiery fashion as first van Bommel's shot drifted wide of the post and then Park miskicked with the goal at his mercy after a delightful step-over by van Bommel on the edge of the area.
PSV were saved at the other end when Lucius covered back from his right-back slot to slide tackle Andrei Shevchenko as he was played in by Kaka and Heurelho Gomes gathered the ball safely.
However justice was done when PSV went 2-0 up and level on aggregate in the 65th minute as Cocu arrived to head home at the far post from a brilliant cross by Park's Korean team-mate Lee Young-pyo, who had outstripped Brazilian World-Cup winning fullback Cafu down the left flank.
Ambrosini should have taken it out of PSV's grasp with 10 minutes remaining as unmarked he had a free header from a corner but it was parried by Gomes and hacked clear.
Ambrosini, though, made no mistake in injury-time as, again unmarked, he met Kaka's cross but his header should have been turned away by Gomes, who instead helped it into the net.
Cocu made sure the Italians could not rest easy as almost immediately he scored with a superb volley after Vennegoor off Hesselink had won the ball and headed it on but while he gave the scoreline on the night a realistic touch, the damage had been done.
Newcastle gets win
Newcastle inflicted a 3-1 defeat on Fulham on Wednesday to end their miserable seven-game run in the Premiership without a win.
Injury, disciplinary problems and poor form have taken their toll with Graeme Souness' men plummeting down the table, but this emphatic win at Craven Cottage will have lightened the mood at St James' Park and lifted the Magpies up two places into 12th.
Their worst ever Premiership finish was 13th on 44 points in 1997-1998 under Kenny Dalglish.
They took full advantage of some dismal defending from Fulham with Darren Ambrose, Patrick Kluivert and Shola Ameobi on target before Tomasz Radzinski cut the deficit in the closing minutes.
With Alan Shearer given the night off, Souness opted to pair Ameobi with Kluivert up front but it was Ambrose who set the visitors on their way to victory in the 18th minute.
The midfielder made the most of a mistake by Alain Goma to foil Edwin van der Sar when he latched onto a header from James Milner to shoot right-footed from the penalty spot.
Fulham went close to an equalizer when former Newcastle player Lee Clark's header inched over the bar -- their best opportunity of the night.
Kluivert, for whom this was a first league game since Boxing Day, put Newcastle further in control just after the hour mark, the Dutch striker pouncing on a Charles N'Zogbia-taken corner from the right.
Milner was at the heart of Newcastle's third when his inswinging corner in the 75th minute was headed in to the top right of the net by Ameobi lurking by the far post.
Radzinski then got a late consolation, running onto Liam Rosenior's pass to slot the ball past Shay Given with four minutes to go.
This was not the way Fulham would have wanted to mark their 150th Premiership game and it left the west Londoners on 38 points, one place behind Newcastle.
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