Chelsea's quest to win four major titles ended when Newcastle ousted the understrength Blues from the FA Cup with a 1-0 victory at St. James' Park on Sunday.
Mourinho started with seven regulars on the bench, hoping to save them for Wednesday's high-profile Champions League match at FC Barcelona.
"We got a great result today against an excellent team," Newcastle manager Graeme Souness said.
Mourniho's strategy went wrong in the fourth minute when Patrick Kluivert gave the Magpies a quick lead, heading in a cross from 8m to the right of diving goalkeeper Carlo Cudicini.
Mourinho had been dubbed the "Portuguese Man of Four." Now he will have to settle for three.
Chelsea leads the Premier League by nine points, goes in as a slight favorite against Barcelona, and plays next weekend in the League Cup final against Liverpool.
With centerback John Terry suspended, Mourinho rested starters Petr Cech, Paulo Ferreira, Frank Lampard, Claude Makelele, Eidur Gudjohnsen and Damien Duff.
Bowing to the tradition of the FA Cup, Mourinho put Lampard, Duff and Gudjohnsen on to start the second half -- using all his substitutions trying to salvage the game.
That move went wrong when winger Wayne Bridge went off with an ankle injury just two minutes into the half, forcing Chelsea to play with 10 men. Three minutes into second-half injury time, 'keeper Cudicini was sent off on a red card.
By the end of the match, Duff and defender William Gallas were limping.
Mourinho said Bridge had "no chance" to play against Barcelona.
Chelsea lost to Manchester City 1-0 in league play, and fell to FC Porto 2-1 in the Champions League.
The FA Cup quarterfinals are sure to have a non-Premier League flavor.
Manchester United, Newcastle and Bolton are in, but Charlton is out after falling to lower-division Leicester. Four Premier League teams -- Arsenal, Southampton, Blackburn and Tottenham -- face replays to advance to the last eight.
Blackburn's 0-0 draw at bitter northern rival Burnley forces a replay at Blackburn. The two venues are separated by only 13km.
Gregory Vignal and Nacho Novo scored second-half goals to lift Rangers to a 2-0 victory over Celtic, pushing the winners into first place in Scotland after the latest showdown between the bitter rivals.
The victory at Celtic's Parkhead gave Rangers 65 points with Celtic on 62. Rangers have played one more game than Celtic.
Vignal scored in the 71st minute on a shot from just outside the box, which Celtic goalkeeper Robert Douglas fumbled. The ball bounced off his hands, over his shoulder and into the net.
Novo scored the clincher in the 82nd.
Gary O'Connor scored two goals and Steven Whittaker and Steven Fletcher scored the others in Hibernian's 4-0 victory over Dundee. The win solidified Hibs' hold on third place with 47 points, followed by Hearts (41) and Aberdeen (39).
Brazilian midfielder Marcos Assuncao scored two goals to lead Real Betis over Deportivo La Coruna 2-0 and into third place.
Defending champion Valencia missed a chance to overtake Betis later in the day when Uruguayan forward Mario Regueiro scored to give lowly Santander a 1-0 win.
The defeat left Claudio Ranieri's team in sixth place and without a league win in six games. It also added to the pressure on the Italian coach, who returned to the club last summer for his second spell.
"We have to keep fighting without fear. Only hard work will get us through," Ranieri was quoted as saying by news agency Efe.
In another 24th-round game, Espanyol's hopes of playing in next season's Champions League suffered a blow with a 3-2 defeat at Malaga. Also, Getafe drew 0-0 with Osasuna, Levante drew 0-0 with Zaragoza, and Numancia edged Albacete 2-1.
In a late match, Uruguay striker Diego Forlan scored his 15th goal of the season to help Villarreal overturn a two-goal deficit and beat Atletico Madrid 3-2.
Osasuna coach Javier Aguirre complained of racist taunting by Getafe spectators, calling it "a macabre joke." Spanish soccer has been hit by an upsurge in racist abuse in recent months.
Barcelona leads the league with 57 points from 24 matches, while Madrid has 50 points. Betis is next with 41 points, ahead of Sevilla on goal difference. Villarreal is fifth with 40 points, two more than Valencia and Espanyol.
Betis extended its unbeaten run to six games and continued its revival after a poor start this season under coach Llorenc Serra Ferrer.
Ailton had a hat trick to help Schalke again pull even with Bayern Munich atop the Bundesliga with a 3-1 win over struggling Borussia Moenchengladbach.
Stuttgart beat Hertha Berlin 1-0 to end its four-game winless streak and snap Berlin's impressive 11-game undefeated run.
Bayern and Schalke both have 44 points, but Bayern has the better goal differential.
Bayer Leverkusen is fourth with 38 points, along with Stuttgart.
Hertha fell to seventh place with 36 points, behind Hamburger SV (37).
Veteran striker Francesco Flachi had a hat trick and Sampdoria beat Reggina 3-2 to tie fourth-place Udinese at 41 points in the Serie A standings.
Palermo and AS Roma also moved closer to the top four spots with victories.
Palermo got two goals from Argentina midfielder Mario Alberto Santana and one by striker Luca Toni in a 3-2 victory over Lecce in the Sicilian capital.
Goals by Vincenzo Montella, Simone Perrotta and Francesco Totti gave the Roman team a 3-0 home win over Livorno.
Defending champion AC Milan joined Juventus atop the league standings with 54 points following a 1-0 injury-time win over Cagliari.
Inter Milan stayed in third place, 11 points behind, with a 1-1 draw at Udinese.
Ten-man Siena downed Fiorentina 1-0 in the Tuscan derby on a first-half goal by Norwegian striker Tore Andre Flo. Lazio beat nine-man Chievo Verona 1-0 on a late goal by Tommaso Rocchi.
Last-place Atalanta ended Bologna's eight-match unbeaten streak with a 2-0 home win. Parma defeated 10-man Brescia 2-1 in a showdown between relegation-threatened sides.
Lille missed the chance to reclaim second place in the French first division when it was held 1-1 in a hard-fought match at Metz.
Slovenia midfielder Milenko Acimovic gave Lille a seventh-minute lead, but Metz replied in the 50th through Ludovic Obraniak's penalty. He was one of seven players booked in a rough contest.
Lille's form has dipped since becoming the only team to beat three-time defending champion Lyon in the league last month.
Since that win, coach Claude Puel's team has drawn four straight, meaning it has tied nine of the last 13 matches -- making a title challenge increasingly unlikely.
The result leaves Lille in third place with 46 points from 26 matches, one behind second-place Marseille and seven behind Lyon, which is edging closer to a record-equaling fourth straight title.
Fanis Gekas scored his third goal since joining Panathinaikos last month, helping the Athens team edge Egaleo 1-0 and move it closer to Greek league leader Olympiakos.
Gekas, who leads the league with 13 goals, scored the lone goal in the 29th minute after goalmouth melee. He got his first 10 goals of the season with Kallithea.
Olympiakos, which lost at 10-man Ergotelis 2-1, still leads the league with 41 points. Panathinaikos is next with 39 points, followed by AEK Athens with 38. AEK beat Iraklis 2-1 on Saturday.
Former Egyptian international Hany Ramzy is retiring with immediate effect and is set to take up a coaching career, his Bundesliga club, Kaiserslautern, said Sunday.
Ramzy, 35, has been sidelined with a knee injury. His contract runs out at the end of the season and with little chance of him becoming a starter again, Ramzy decided to retire, the club said.
He will start a coaching course Monday and will later join Kaiserslautern's junior coaching staff, the club said.
Ramzy joined Kaiserslautern in 1998 after four years at Werder Bremen. He had 22 Bundesliga games as a defender and midfielder and scored 15 goals. Ramzy had 124 caps for Egypt.
Andriy Shevchenko injured
Striker Andriy Shevchenko of AC Milan was released from the hospital Sunday, but will require surgery to fix a cheekbone fracture.
The Milan club said it was not immediately clear how long the Ukraine international would be sidelined, but he will certainly miss this week's Champions League match against Manchester United and next Sunday's derby with crosstown rival Inter Milan.
Shevchenko, recently named Europe's best player of 2004, was injured during the first half of Milan's Serie A match against Cagliari, which Milan won 1-0. He was butted in the face by a Cagliari defender as they were trying to head the ball.
"Sheva," who has scored 14 goals this season, spent the night in a Milan hospital pending examinations. AC Milan officials said the surgery will be performed within a few days.
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