Neffa-De Los Rios held a 3-1 lead in the second set before Myskina was able to find her game again and take a 6-5 lead. Neffa-De Los Rios won her service game to force the tiebreaker, but Myskina shut her out the rest of the way.
For the second straight match, sixth-seeded Vera Zvonareva was pushed to the brink before beating her opponent, Nathalie Dechy of France, 2-6, 6-3, 6-4.
Another Russian, seventh-seeded Nadia Petrova defeated Amy Frazier of the United States 6-4, 6-3, and eighth-seeded Alicia Molik of Australia beat Jelena Jankovic of Serbia-Montenegro 7-5, 6-3.
Venus Williams needed a third-set tiebreaker to defeat 87th-ranked Yuliana Fedak of Ukraine, 6-4, 2-6, 7-6 (4). Williams, the fifth seed, led 5-4 in the first set but Fedak fought off six set points before losing on the game's eighth deuce. Fedak easily won the second set and opened a 3-1 lead in the third, but Williams fought back for a 5-4 lead.
Abigail Spears upset No. 4 seed and fellow American Jill Craybas 6-1, 6-2 Thursday to advance to the third round of the tournament.
Mary Pierce, the tournament's top seed, also won her second-round match with a 6-3, 6-4 victory over challenger Mariana Diaz-Oliva.
Stephanie Dubois of Quebec lost to Alina Jidkova of Russia.
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