Rasheed Marshall set a Big East career rushing mark for quarterbacks and threw three touchdown passes while leading No. 15 West Virginia over 27-6 Thursday night.
Jason Colson had 113 yards against the league's worst rushing defense, and Chris Henry caught two TD passes against the Orangemen for the second straight season.
The Mountaineers (6-1, 2-0) took sole possession of first place in the conference by scoring the first 17 points and stopping four Syracuse drives inside the red zone without points.
Syracuse (3-4, 1-1) now must win three of its final four games to become bowl eligible. Each loss by the Orange has been to a ranked team.
Marshall owns league records once held by Syracuse's Donovan McNabb and Virginia Tech's Michael Vick.
Marshall's 87 rushing yards Thursday gave him 1,605 for his career, breaking McNabb's mark of 1,561.
In 2002, Marshall set the single-season mark of 666 formerly held by Vick.