He got his 321st win, moving three behind Nolan Ryan and Don Sutton, who share 12th place on the career list. Clemens allowed two runs and four hits in seven innings, striking out five to raise his career total to 4,099.
"Our guys jumped out there and gave me a lead, and that makes you want to hang on," Clemens said. "We scored some runs late, just like we used to when we were winning early this season."
Brad Lidge got his eighth save in 10 chances, and Carlos Beltran, Jeff Kent and Craig Biggio hit solo homers.
Cardinals 10, Reds 4
In Cincinnati, Mike Matheny drove in three runs and Jeff Suppan won his third straight start.
Edgar Renteria and Reggie Sanders hit solo homers for the Cardinals, who won for the 11th time in 13 games.
Suppan (9-5) allowed four runs and seven hits in six-plus innings.
Jose Acevedo (4-8) gave up six runs, seven hits and three walks in 2 1-3 innings, his shortest outing of the season other than an outing shortened by a rain delay. Acevedo allowed five runs in one inning for the second consecutive start.
Mets 6, Phillies 1
In New York, Al Leiter pitched six shutout innings, and Mike Cameron and Vance Wilson hit back-to-back homers in the fifth off Brett Myers (5-7).
Leiter (6-3) allowed four hits and struck out a season-high seven for his fifth win in six starts as the Mets salvaged a split of the four-game series.
Wilson and Cameron each drove in two runs for the Mets, who moved a game above .500 at 46-45 -- two games behind Philadelphia and Atlanta in the NL East.
Braden Looper got four outs for his 19th save in 21 chances.
Rockies 10, Giants 9
In Denver, Jeromy Burnitz and Preston Wilson each homered off Matt Herges (4-4) and Aaron Miles capped Colorado's four-run ninth inning with an RBI single.
Colorado turned the tables on the Giants after a disheartening 7-5 loss to the Giants on Thursday in which closer Shawn Chacon gave up four runs in the ninth inning.
San Francisco led 9-6 heading into the bottom of the ninth after Deivi Cruz hit a tiebreaking homer to lead off the eighth and Michael Tucker and Barry Bonds hit solo shots in the top half.
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