Reggie Sanders homered and had an RBI double, and Albert Pujols drove in three runs and scored three times.
John Mabry had a three-run homer in the sixth, and Scott Rolen drove in his major league-leading 77th run.
Ichiro Suzuki had two hits in Seattle's first regular-season game at St. Louis. The Mariners lost for the eighth time in 11 games.
Matt Thornton (0-1) relieved starter Jamie Moyer after the delay.
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