His second was a fortunate affair five minutes from the end as he deflected Mark van Bommel's free kick past wrong-footed NEC goalkeeper Dennis Gentenaar, taking his season tally to 24.
The Serb's nearest rivals are three strikers on 14 goals, so his leading marksman title is not under threat.
And it was Kezman's dribble which created the chance for Van Bommel to slot the third in the 88th.
Before the first goal, PSV's only reasonable chance also fell to Kezman, but only because NEC defender Robbie Wielaert lay prone in his own box playing the Serb onside.
NEC striker Frank Demouge lost Juergen Collin to test Ronald Waterreus at the near post early in the second half and whacked the ball against a post.
But until the late goals came, most of the second half entertainment was provided by an amusingly chaotic NEC offside trap, which repeatedly sent PSV runners in vain into huge areas of space.
Bert Zuurman's winner boosted lowly FC Zwolle to a 1-0 upset win over SC Heerenveen, which prevented the northern side from leapfrogging over Feyenoord into third.
Zwolle climbed into 16th above Vitesse Arnhem, which drew 1-1 with Willem II Tilburg on Friday, but remains four points adrift of ADO The Hague, which downed FC Twente Enschede 1-0.
French League
Goalkeeper Teddy Richert proved the hero as Sochaux won the League Cup for the first time, defeating Nantes 5-4 on penalty kicks.
With the score tied 1-1 after extra-time, the match went to spot kicks and Richert, who had an outstanding match, dived low to his right to palm away Pascal Delhommeau's weak strike.
The win means Sochaux, last year's losing finalist, automatically qualifies for next season's UEFA Cup competition.
Nantes started much the brighter and in the 10th minute, midfielder Frederic Da Rocha headed over from close range with the goal at his mercy.
Four minutes later, Pujol gave Nantes the lead when he stretched athletically to connect with a cross from the right and send his volley under the body of Richert.
Although largely dominated in the opening stages, Sochaux leveled in the 19th minute when defender Sylvain Monsoreau headed a left-wing cross clinically past stranded 'keeper Mickael Landreau.
Nantes defender Mario Yepes then denied Sochaux's Santos with a last-ditch challenge, just as the Tunisia striker was about to shoot.
Both sides failed to create chances for the remainder of the first-half and entered the interval tied at 1-1. Nantes started the second-half strongly and striker Viorel Moldovan broke through on goal, only to be thwarted by Gregory Paisley's tackle.
Sylvain Armand's injury-time header narrowly missed the target as Nantes pressed for a winner.
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