Bledsoe engineered scoring drives of 80 and 90 yards on his first two possessions.
Panthers 24, Jaguars 23
In Charlotte, North Carolina, Jake Delhomme replaced an ineffective Rodney Peete at the start of the second half and energized Carolina's rally with three touchdown passes.
Delhomme, one of a handful of offseason additions brought in to revamp Carolina's sluggish offense, threw a 12-yard touchdown pass to Ricky Proehl on fourth-and-11 with 16 seconds remaining to win it.
Seth Marler attempted a 55-yard field goal as time expired, but Mike Minter blocked the kick and new Jacksonville coach Jack Del Rio lost in his NFL debut.
Giants 23, Rams 13
In East Rutherford, New Jersey, Kenny Holmes recovered one of Kurt Warner's six fumbles for a touchdown, and the Giants sacked the St. Louis Rams' quarterback six times and intercepted him once. Warner went to the hospital after the game with a concussion. A CT scan and X-rays on his neck and head taken Sunday night were negative.
New York forced four turnovers and each started a drive that led to points.
Vikings 30, Packers 25
In Green Bay, Wisconsin, Randy Moss caught nine passes for 150 yards and a touchdown as the Vikings won in front of a record crowd of 70,505 at remodeled Lambeau Field.
The Vikings, who snapped a 12-game losing streak outdoors, built a 27-3 lead and held off Green Bay's furious rally. The Vikings forced four turnovers, including three interceptions by Brett Favre, who hadn't been picked off that many times in the first half since 1995.
Other results: Chiefs 27, Chargers 14; Lions 42, Cardinals 24; Steelers 34, Ravens 15; Broncos 30, Bengals 10; Colts 9, Browns 6.
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