Lack of sleep leads to groggy genes, study 研究:睡眠不足導致基因無力

Wed, Aug 14, 2013 - Page 11

Lack of sleep has a potentially harmful effect on gene expression, according to a study out on Aug. 6 that sheds light on the link between sleep deficits and a wide range of health conditions.

Lack of adequate shut-eye had already been linked to conditions from heart disease and cognitive impairment to obesity. But sleep researcher Derk-Jan Dijk and his fellow researchers have delved into the molecular mechanisms behind the phenomenon, looking at how missed sleep leads to health problems.

They found that a week of sleeping six hours or less a night affects the expression of some 711 genes, including those involved in inflammation, immunity, and stress responses.

Compared with test subjects who were allowed to sleep as long as 10 hours a night, those who lacked sleep had irregularities in their genes’ circadian rhythms.

(AFP)

八月六日公布的一份研究說明睡眠不足與多項疾病的關聯性,根據研究,睡眠短缺可能有害基因表現。

缺乏足夠的闔眼已被與多項疾病連結,從心臟病、認知障礙到過胖等。但睡眠研究人員狄克與研究員同僚更深入這種現象背後的分子機制,研究睡眠不足如何導致健康問題。

他們發現,一週內每天睡眠不超過七小時,影響約七百十一種基因表現,包括與發炎、免疫、壓力反應等有關的基因。

此外,相較於一晚得以睡長達十小時的受試者,缺乏睡眠者的基因生理時鐘紊亂。

(法新社/翻譯:自由時報國際新聞中心)