Genetically engineered virus kills cancer 基因工程改造病毒殺死癌細胞

Wed, Mar 06, 2013 - Page 10

A genetically-engineered virus tested in 30 terminally-ill liver cancer patients significantly prolonged their lives, killing tumors and inhibiting the growth of new ones, scientists reported.

Sixteen patients given a high dose of the therapy survived for 14.1 months on average, compared to 6.7 months for the 14 who got the low dose.

“For the first time in medical history we have shown that a genetically-engineered virus can improve survival of cancer patients,” study co-author David Kirn said.

The four-week trial with the vaccine Pexa-Vec, or JX-594, reported in the journal Nature Medicine may hold promise for the treatment of advanced solid tumors.

Pexa-Vec “is designed to multiply in and subsequently destroy cancer cells, while at the same time making the patients’ own immune defence system attack cancer cells also,” said Kirn from California-based biotherapy company Jennerex.

Pexa-Vec has been engineered from the vaccinia virus, which has been used as a vaccine for decades, including in the eradication of smallpox.

(AFP)

一種測試於三十名肝癌末期病患的基因工程改造病毒,明顯延長他們的生命、殺死腫瘤,並抑制新腫瘤的生長,科學家報告說。

十六名施以高劑量治療的病患平均存活十四點一個月,相較於十四名獲低劑量治療者的六點七個月。

「這是醫學史上我們首度顯示,基改病毒能延長癌症患者的生命,」該研究共同撰文者大衛.柯恩說。

這項報告於《自然醫學》期刊、針對疫苗Pexa-Vec或稱JX-594進行的四週實驗,或許給末期固體性腫瘤的治療帶來希望。

Pexa-Vec「被設計在癌細胞內繁殖,接著摧毀癌細胞,同時也使患者自身的免疫防衛系統攻擊癌細胞,」來自總部設於加州的生物治療公司Jennerex的柯恩說。

Pexa-Vec是從基因改造牛痘病毒而來,數十年來該病毒被用作疫苗,包括用於根絕天花。

(法新社/翻譯:魏國金)