"Doing so will make a significant contribution to global health security," the letter said.
The letter's signatories included Trent Lott, former Senate majority leader and the newest co-chairman of the Senate's Taiwan Caucus, and former Democratic vice presidential contender, Joseph Lieberman.
The letter comes a week after 27 members of the US House of Representatives sent a letter to European Commission president Jose Manuel Barroso urging the EU to publicly support Taiwan's observer status, saying that by doing so, the EU would "provide significant momentum to this proposal."
While Japan shares the US' support of observer status, the EU is "lagging a little behind," and does not support it, Wu said.
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