Mon, Dec 09, 2019 - Page 7 News List

China is racing to develop a super pig

Scientists in China, the US and Europe are working to create more healthy pigs that could even be resistant to African swine fever

By Kristine Servando  /  Bloomberg

Illustration: Yusha

Inside a fortress-like megafarm on the outskirts of Beijing, dozens of pink-and-black pigs forage and snooze, unfazed by the chilly spring air. These experimentally bred hogs are fortified with a gene for regulating heat, buffering them against northern China’s hypothermia-inducing winters.

The gene that researcher Zhao Jianguo (趙建國) inserted into the pigs’ DNA is among dozens of examples of genetic engineering under way in China — and in rival laboratories across the world — to create super pigs.

For years, the quest was for better-tasting, stronger and faster-growing swine. Now, in the wake of a devastating global outbreak of African swine fever, the more crucial need is to safeguard food security, and keep hogs alive.

“The most burning question for scientists is how to make the pig more healthy,” said Zhao, 45, who heads a 20-strong group of researchers and technicians at the state-run Chinese Academy of Sciences’ Institute of Zoology in Beijing, where he has become a superstar in the world of swine genomics.

However, China’s ambitions extend well beyond farm animals. In dozens of labs across the country, scientists are racing researchers in the US and Europe to develop superior lines of food and fiber crops, while others are pushing the boundaries of medical science — sometimes facing criticism — by editing the human genome to correct disease-causing mutations or susceptibility to infections like HIV.

It is a biotechnology arms race happening against the backdrop of a disruptive trade dispute with the US, a rapidly aging population and diminishing resources to feed China’s 1.4 billion people. Soaring pork prices prompted the Chinese State Council in September to call for the greater use of science and technology, among other measures, to boost production of the country’s staple meat.

China’s investment in research and development has already catapulted the world’s most populous nation from relative obscurity in biomedical science to behemoth in less than two decades.

China outspends every other country barring the US on research and development — US$445 billion in 2017. Chinese firms have also stepped up acquisitions of foreign biotechnology and pharmaceutical companies, with US$25.4 billion in deals since the start of 2014, data compiled by Bloomberg showed.

Yet teams in the US and Europe have a critical edge, including something China desperately needs: protection from major pig-killing diseases.

China has sought to redress that by sending abroad promising scientists, like Zhao, to learn from the world’s best, then bringing them home and furnishing them with industrial-scale resources. The campus that houses Zhao’s gene-edited pigs is ring-fenced by three layers of security checkpoints and can accommodate 4,000 hogs.

“The powerhouse these days is China,” said Simon Lillico, 47, a scientist at the University of Edinburgh’s historic Roslin Institute, where Dolly the sheep became the first mammal cloned from an adult cell in 1996. “They are spending so much money and throwing so much resource at science that we can’t even come close to competing with the amount of money that they are investing in this sort of science, so we need to be smart about what we do.”

China’s market for biologic drugs and agricultural biotechnology remains a fraction of the US’ estimated US$228 billion industry, but the upsurge in Chinese investment is already causing anxiety in Washington.

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