Tue, May 01, 2012 - Page 9 News List

Cancer by the numbers

Although it appears counterintuitive to many people, widespread testing for cancer can often cause more harm than good, as a look into the statistics demonstrates

By John Allen Paulos

Illustration:Yusha

It is difficult to communicate medical risk to a large audience, especially when official recommendations conflict with emotional narratives. That is why, when the US Preventive Services Task Force (USPSTF) in 2009 presented its guidelines for breast cancer screening, which recommended against routine screenings for asymptomatic women in their 40s and biennial, rather than annual, mammograms for women over 50, the public responded with confused fury.

The key to understanding this response is to be found in the nebulous zone between mathematics and psychology. People’s discomfort with the findings stemmed largely from faulty intuition: If earlier and more frequent screening increases the likelihood of detecting a possibly fatal cancer, then more screening is always desirable. If more screening can detect breast cancer in asymptomatic women in their 40s, would it not also detect cancer in women in their 30s? And, if so, why not, reductio ad absurdum, begin monthly mammograms at age 15?

The answer, of course, is that such intensive screening would cause more harm than good, but striking the proper balance is challenging. Unfortunately, it is not easy to weigh breast cancer’s dangers against the cumulative effects of radiation from dozens of mammograms over the years, the invasiveness of biopsies and the debilitating impact of treating slow-growing tumors that would never have proven fatal.

The task force recently issued an even sharper warning about the prostate-specific antigen test for prostate cancer, after concluding that the test’s harms outweigh its benefits. Chest X-rays for lung cancer and Pap tests for cervical cancer have received similar, albeit less definitive, criticism.

The next step in the re-evaluation of cancer screening was taken last year, when researchers at the Dartmouth Institute for Health Policy announced that the costs of screening for breast cancer were often minimized and that the benefits were much exaggerated. Indeed, even a mammogram (almost 40 million are given annually in the US) that detects a cancer does not necessarily save a life.

The Dartmouth researchers found that, of the estimated 138,000 breast cancers detected annually in the US, the test did not help between 120,000 and 134,000 of the afflicted women. The cancers either were growing so slowly that they did not pose a problem, or they would have been treated successfully if discovered clinically later (or they were so aggressive that little could be done).

A related concern is measurement. Since the patient’s duration of survival is calculated from the time of diagnosis, more sensitive screening starts the clock sooner. Survival times can thus appear longer, even if the earlier diagnosis had no real effect on survival.

Naturally, individual cases dictate which tests and treatments are best, but an additional concern about frequent screenings is the problem of false positives. When one is looking for something relatively rare (whether cancer or terrorists), it is wise to remember that a positive result is often false. Either the “detected” pathology is not there, or it is not the sort that will kill you.

Consider the following hypothetical example. Assume that the screening test for a certain cancer is 95 percent accurate, meaning that if someone has the cancer, the test will be positive 95 percent of the time. Next, assume that if someone does not have the cancer, the test will be positive only 1 percent of the time. Finally, assume further that 0.5 percent of people — one of every 200 — actually have this type of cancer. If your doctor tells you that you have tested positive, does this mean that you are likely to have the cancer? Surprisingly, the answer is no.

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