Sat, Dec 24, 2005 - Page 9 News List

Sooner or later, the dilemmas of embryo research will hit home

By Peter Singer

What appeared to be the most momentous scientific advance of the year is currently under siege. In June, the prestigious journal Science published an article by the South Korean scientist Hwang Woo-suk and an international team of co-authors describing how they had developed what were, in effect, "made to order" lines of human stem cells cloned from an adult. Although the scientific validity of their research is now the subject of several separate investigations, it is no less important to examine its ethical implications.

Hwang and his colleagues claimed to have replaced the nucleus of an unfertilized human egg with the nucleus of an ordinary cell taken from another person, developing stem-cell lines from the resulting embryo that matched the DNA of the person who supplied the ordinary cell.

That achievement appeared to take us significantly closer to a world in which patients could be given cell or tissue transplants that their bodies would not reject, because the biological materials, cloned from the patients themselves, would be a perfect match.

At the beginning of this month, Hwang disclosed that some of the eggs came from two women working in his lab, and that other "donors" had been paid for their eggs -- a breach of ethical guidelines that had nothing to do with the accuracy of the science.

But then Hwang's collaborators began questioning the validity of the experiment itself, and Hwang notified Science that he wished to withdraw the paper. At the time of writing, he still defends the validity of his work, while admitting "human errors" in the preservation of the stem-cell lines, including contamination by a fungus. He has reportedly even suggested that some cells may have been tampered with.

We will not know how close we are to the production of individually tailored stem-cell lines until the scientific investigations into Hwang's research are completed. Nevertheless, few researchers doubt that what Hwang and his colleagues claimed to have done is, in principle, achievable. If Hwang was not the first to do it, someone else eventually will be. Once it can be done reliably, it will pave the way for important medical breakthroughs.

But the ethical significance of such research goes far beyond the undoubted importance of saving critically ill patients. Proving the possibility of cloning from the nucleus of an ordinary human cell would transform the debate about the value of potential human life, for we would find that "potential human life" was all around us, in every cell of our bodies.

For example, when US President George W. Bush announced in 2001 that the US would not fund research into new stem-cell lines that are created from human embryos, he offered the following reason: "Like a snowflake, each of these embryos is unique, with the unique genetic potential of an individual human being."

But it is precisely this reasoning that is threatened by what Hwang and his team claimed to have achieved.

If it is the uniqueness of human embryos that makes it wrong to destroy them, then there is no compelling reason not to take one cell from an embryo and destroy the remainder of it to obtain stem cells, for the embryo's "unique genetic potential" would be preserved.

This possibility highlights the weakness of the argument that abortion, too, is wrong because it destroys a genetically unique human being. By this reasoning, a woman who finds herself pregnant at an inconvenient time could have an abortion, as long as she preserves a single cell from the fetus to ensure that its unique genetic potential is preserved.

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