The Hang Seng Index closed down 32.19 points at 16,912.15.
The Hang Seng has been trading this week at its highest levels in six years.
Shanghai share prices closed 2.24 percent higher, led by oil major and market heavyweight Sinopec as stocks chalked up their biggest single-day gain in more than two months.
The Shanghai A-share Index rose 32.55 points to 1,485.93 and the Shenzhen A-share Index was up 1.98 points or 0.55 percent at 360.85. The benchmark Shanghai Composite Index, which covers A and B-shares, closed up 30.89 points or 2.23 percent at 1,416.79, an 18-month high.
Sydney share prices closed down 0.51 percent on profit-taking in resource stocks although the market's fall was limited by gains in the banking sector.
The S&P/ASX 200 index dropped 26.8 points to 5,250.1.
Singapore share prices rose 0.76 percent for another record finish, this time above 2,600 points as investors bought in ahead of general elections in May and upcoming quarterly results.
The Straits Times Index added 19.72 points at 2,603.45.
Malaysian share prices closed O.17 percent higher due to follow-through buying driven by the ringgit's strength against the dollar which outweighed inflation fears.
The composite index rose 1.57 points to 948.19.
Bangkok share prices closed 0.19 percent lower on profit-taking after rising to a two-year high as softer oil prices led the key energy-linked stocks down. The composite index fell 1.51 points to 773.06.
Mumbai share prices closed broadly flat, recovering from a sharp early selloff, and remained above the key 12,000 level.
The 30-share SENSEX index closed down 9.2 points or 0.08 percent at 12,030.3 after crossing the historic 12,000 level on Thursday, powered by domestic funds buying.
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